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Our data highlight that APP treatment can enhance the antioxidant capacity of the serum, which is closely related to the up-regulated GSH level, GSH/GSSG ratio and antioxidant enzymes within serum after APP treatment

Synthesis of soluble peptides was performed on automated peptide synthesizer Tribute from Protein Technologies (AZ, Tucson, USA)

Ethanol metabolism alters the cytosolic and mitochondrial redox states [NADH/NAD + ] and it may exacerbate mitochondrial ROS production by increasing the flow of electron down the respiratory chain

The primary goal is to determine whether aggressive lowering of glucose levels can prevent the loss of beta cell function that characterises the transition from impaired glucose tolerance to diabetes