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[32] NTDs occur early in pregnancy (first month), therefore women must have abundant folate upon conception and for this reason there is a recommendation that any woman planning to become pregnant consume a folate-containing dietary supplement before and during pregnancy

Hence, there is a general lack of a standardized reporting procedure for MS/MS spectra acquisition and metabolite annotation

This prevalence is notably higher among patients with severe obesity, those from high-risk ethnic groups, or those already diagnosed with T2DM, underscoring the conditions association with metabolic abnormalities (10, 11)