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DGUOK mediates the phosphorylation of deoxyguanosine and deoxyadenosinepurine into the corresponding nucleotides in mitochondria and its deficiency creates an imbalance in the mitochondrial dNTPs pool that affects mtDNA synthesis

Molecules 25, 2173

However, it has been observed that SOD levels and activity decrease when the skin is exposed to greater amounts of sunlight

A., Ahmad, I., & Althubiani, A

When animals were treated with the mitochondria-targeted MnSOD mimetic Mito-TEMPO, the prevention of peroxynitrite formation due to superoxide dismutation eliminated necrotic cell death 6 h after APAP administration with no evidence of apoptosis [29, 58]