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Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation

Biochimie 94 , 588596 (2012)

One study demonstrated that apatinib inhibited the expression of GLS1, activated the GCN2/eIF2/ATF4 pathway, and promoted the expression of SLC1A5, thereby reprogramming Gln metabolism in NSCLC and weakening the response of tumor cells to apatinib (33)