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Nat Rev Mol Cell Biol (2020) 21:36383

They typically start with history, symptoms, and ruling out more common causes (sleep disorders, thyroid issues, depression/anxiety, overtraining, medication effects)

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Curcumin-mediated decrease in the expression of nucleolar organizer regions in cervical cancer (HeLa) cells

Therefore, while PDOs serve as an invaluable tool for understanding the intrinsic properties of chemoresistant tumor cells, they cannot fully capture the extrinsic factors that contribute to resistance