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Because PPIs are sensitive to degradation by strong acid, they have a limited half life within the acidic canaliculi, which can lead to less than maximal effect during the first ~3 days of therapy, and inadequate elevation of gastric pH without repetitive dosing

But our other recommendations are effective in their own rights

Uremia and chronic kidney disease: the role of the gut microflora and therapies with pro- and prebiotics

[,] However, a study by Liu et al [] did not observe a substantial reduction in PCa in transgenic adenocarcinoma of the mouse prostate (TRAMP) after being fed a high broccoli sprout diet

Vegan and vegetarian athletes almost certainly need supplementation, as do those over 50 whose absorption naturally declines