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however, recent findings indicate that amyloid formation in vivo may be promoted by disulfide bond formation between TTR subunits, suggesting oxidative stress as a potential contributor to protein misfolding and disease progression

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E., & Maenhaut, C

doi: 10.1093/brain/awac389 119 O'CarrollSJKhoDTWiltshireRNelsonVRotimiOJohnsonRet al

The management of GBM is hampered by several challenges, including tumour heterogeneity, the presence of therapy-resistant glioma stem cells, the highly infiltrative growth pattern of tumour, primary and acquired drug resistance, and BBB, which restricts drug delivery 7,8,27,28,29