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PBITV3: a robust and comprehensive tool for screening pathogenic proteomes for drug targets and prioritizing vaccine candidates

10.1016/j.brainresbull.2022.11.005 Brain Res

8.5.2 In vitro modification In vitro modification is performed directly on purified EVs, offering advantages such as operational controllability and high yield

IT DFO could potentially cause neurotoxicity if the local concentration is too highhigh doses of systemic DFO have been associated with neurotoxic effects (e.g., hearing loss, seizures) (Zhang et al., 2025), and these risks would potentially be higher through direct CNS exposure

For cancer, modulating GPx4 to induce ferroptosis offers a strategy against therapy-resistant tumors, while in cardiovascular care, boosting GPx could reduce inflammation and plaque formation