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50 Spontaneous intramolecular rearrangement and elimination of the carbamate group at C10 of mitomycin C results in a second alkylation reaction with the opposite strand of DNA to induce cytotoxic 1,2-GG interstrand crosslink lesions (Figure 7)

Taken together, these studies revealed that metabolites can regulate both inflammatory and anti-inflammatory processes, in addition to intracellular metabolism and energetics