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Investigations are guided by clinical suspicion rather than routine panels: for example, thyroid function tests and ferritin may be checked if symptoms suggest deficiency or thyroid disease, while an androgen profile may be appropriate in women presenting with menstrual irregularity, hirsutism, or acne

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93 These findings suggest that BH 4 deficiency and decreased eNOS activity cause endothelial dysfunction in elderly subjects and in patients with hypertension through an increase in oxidative stress

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Low CSF GABA in Parkinsonian patients who respond poorly to therapy or suffer from the on-off phenomenon