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Rather are potential changes, as observed under pathological conditions, the consequence of metabolic disturbances such as deficiencies or exhausted capacity of enzymes that require GSH or other thiols as substrates

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Under these circumstances a thiyl radical is formed that will initiate and propagate an oxygen-dependent chain reaction, involving peroxyl radical formation that will lead to further consumption of intracellular GSH (Quijano et al., 1997)

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Please note that dissolving fillers may take multiple sessions, depending on the type of filler and amount used