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In this Perspective, we propose that inhibition of ferroptosis by GPx4 provides protective mechanisms against neurodegeneration

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Annu Rev Biochem 52:711760 Mieyal JJ, Gallogly MM, Qanungo S, Sabens EA, Shelton MD (2008) Molecular mechanisms and clinical implications of reversible protein S-glutathionylation

We aim to pose a perspective for targeting the disease-associated glia to ameliorate the symptoms and revert the disease phenotypes and senescence for human wellness