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Doseinjury relationship: When NAPQI production exceeds glutathione supplythrough high single doses, high cumulative daily doses, or impaired conjugation/low GSHcentrilobular hepatic necrosis can occur

The endothelial cells are tightly connected by intracellular junctions that play a crucial role in maintaining the highly selective permeability of the BBB, allowing it to regulate the movement of ions, molecules, and cells between the blood and the neural tissue (84, 85)

A forward genetic screen for Arabidopsis mutants with up-regulated GSTF8 promoter activity was conducted by fusing a GSTF8 promoter fragment to the luciferase reporter gene

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While estimating a wild species maximum lifespan is challenging, Greenland sharks are thought to live to about 400, give or take a century [1]