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Hypermutation in human cancer genomes: footprints and mechanisms

Until consolidated evidence emerges, clinicians should approach ozone therapy with circumspection, calibrating its use based on individual patient needs and clinical contexts

The ferroptosis inducers include inhibitors targeting system Xc - (sorafenib) [55] and GPX4 (RSL3) [56], with ability to induce the accumulation of lipid peroxides [57], and directly suppressing GCL (L-buthionine sulfoximine, BSO) leading to GSH depletion [58]

The evolutionary dynamics of the human NADPH oxidase genes CYBB , CYBA , NCF2 , and NCF4 have functional implications

A comprehensive approach involving evidence-based pharmacological treatments to improve bone mineral density, along with multidisciplinary strategies for fragility fracture prevention and management, would likely yield the most beneficial outcomes for elderly patients with osteoporosis [140, 141]