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Although the MT1 and MT2 receptors feature fairly conserved binding pockets for melatonin, they also take distinctive conformational states that modulate ligand selectivity, important for designing subtype-specific therapeutics [39]

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Preclinical evaluation of benzazepine-based PET radioligands (R)- and (S)-(11)C-Me-NB1 reveals distinct enantiomeric binding patterns and a tightrope walk between GluN2B- and (1)-receptor-targeted PET imaging