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As FDA states in their guidance document on the Q-Submission program, Early interaction with FDA on planned non-clinical and clinical studies and careful consideration of FDAs feedback may improve the quality of subsequent submissions, shorten total review times, and facilitate the development process for new devices. While this is not meant to be a general pre-review of your submission, it is there to help you get answers to questions directly from FDAwhich will contribute to a smooth submission and, hopefully, approval

Notably, in these preliminary experiments mast cells from the AD patient exhibited a higher release of CysLTs compared to those from the HVs, both in the non-stimulated samples and in the histamine- stimulated cells (Supplementary Fig

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