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Associated with elevated NAD+ levels and SIRT1 activation in preclinical studies [2] [3]

It modulates inflammation by regulating the production of pro-inflammatory and anti-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-) and interleukin-10 (IL-10) (Drge & Breitkreutz, 2000)

Because it is unclear whether biological oxidations and cellular metabolism program directly affect hair cells using this analysis approach, we performed a gene set enrichment analysis (GSEA) using 983 differentially expressed genes (DEGs), which reveals a list of DEGs are enriched in gene ontologies related with appendage development (Supplementary Figure 3b) or positive regulation of canonical Wnt signaling (Fig