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Basing that, we assumed this discrepancy stemmed from the inability of co-culture system in vitro to fully simulate in vivo cellular communication dynamics, and which may be caused by the low concentration of interleukins from original pyroptotic hepatocytes in the co-culture system, which was insufficient to drive M1 polarization of macrophages

10.1046/j.1471-4159.2000.0751219.x 12 BattagliaV.CompagnoneA.BandinoA.BragadinM.RossiC

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