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Inducing on purpose a PEM (266, 310) with potentially severe consequences is ethically questionable unless appropriate precautions are taken, which is feasible (311)

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These include its comparatively high utilization of oxygen and therefore generation of free radical byproducts, its modest antioxidant defenses, its lipid-rich constitution that provides substrates ready for oxidation, the reducing potential of certain neurotransmitters, and the presence of redox-catalytic metals, like iron and copper (47)

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Studies are beginning to find regenerative benefits that may alleviate symptoms of: Most adults saw results after 12 weeks of consistent treatment combined with a healthy diet and exercise