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This study explores a new source of immunogenic polypeptides originating from a nonconventional open reading frame within human insulin mRNA, which can be targeted by cytotoxic CD8 + T cells present in individuals with T1D, potentially contributing to -cell destruction in the disease

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Patients sought an emergency hospital visit after a median of nine days from symptoms onset and 134 were hospitalized

This multivalency not only strengthens the binding affinity between PROTAC molecules and target proteins but also promotes efficient formation of ternary complexes (POI: PROTAC: E3 ligase), substantially enhancing degradation efficacy

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