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This is due to the age-related wear and tear of shoulder structures, like cartilage

Overall, NAb breadth was limited, but again we observed that E2E1-NPs elicited a broader and more potent NAb response than E2 when comparing the GGMT of the 16 viruses (median GGMT of 37 for E2E1-NPs versus 27 for E2, p = 0.048)

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mouth ulcers Numbness and tingling (pins and needles) in the hands or feet Difficulty walking and problems with balance Vision changes Memory loss and confusion Slower thinking Depression and irritability Diarrhea or constipation

The condition, histoplasmosis, is an example of a multiple coding, as illustrated below