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As people age, their bodies often become less efficient at absorbing and metabolizing nutrients due to changes in gastrointestinal function, such as decreased stomach acid production or altered gut flora

Dose may be increased to 7.2 mg subcutaneously once weekly on patients who tolerate the 2.4 mg dosage for at least 4 weeks and additional weight reduction is clinically indicated

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Excess B12 is excreted in urine, making toxicity extremely rare and high-dose supplementation generally safe

Self-administering unregulated injectable substances carries serious risks, including infection, embolism, and systemic toxicity