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+ Rutin caused a decrease by about 50%

36 At present, colonoscopy is one of the most commonly used methods to confirm UC via direct observation of the pathology of the colonic mucosa or collection of samples for tissue biopsy

Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions

and Zhao et al., respectively, observed marked attenuation of symptoms, histopathological signs of inflammation, and reductions in pro-inflammatory cytokines [62, 63]