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(III) Early efforts characterizing ferroptosis have predominately focused on examining characteristic hallmarks, while less is known about the exact mechanisms that drive the phenotype [83]

However, their clinical translation remains hampered by beyond-rule-of-five (bRo5) physicochemical liabilities, including high polarity, limited membrane permeability, and unpredictable pharmacokinetic behavior, which collectively lead to suboptimal bioavailability and risks of non-specific systemic distribution

The concentration of siRNA in each experimental group was 200 nM

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The role of environmental factors in autoimmune thyroiditis