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The binding of trivalent arsenicals to thiols in intracellular and cell surface proteins often results in aberrations of normal cellular processes including alteration of cellcell communication

One idea is to enhance the activity of amino acid metabolism of CAR-T cells by adding cytokines that promote the expression of transporters related to amino acid metabolism, such as SLC1A5, SLC3A2 and SLC7A5, or directly importing transcripts encoding these AATs into T cells

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Unlike traditional drugs that have a broad effect on the immune system, biologics are designed to block specific inflammatory proteins, such as tumor necrosis factor-alpha (TNF-alpha), which plays a key role in many inflammatory conditions [5]

Hooven LA, Sherman KA, Butcher S, Giebultowicz JM (2009) Does the clock make the poison