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Reduced NAD+ levels contribute to visible signs of aging such as wrinkles, fine lines, and sagging skin

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Calreticulin (CALR) indicates ER enrichment

Eligibility criteria The article selection procedure was divided into two stages

Because of the difficulty of identifying specific sinusoidal cell types from H&E-stained sections, definitive diagnosis of endothelial cell hypertrophy/karyomegaly requires confirmation using special stains