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Personalized whole-body models integrate metabolism, physiology, and the gut microbiome

These are perhaps best exemplified by the mucolytic agent dornase alfa (recombinant human DNase), which is widely used and effective in CF but has been shown to be ineffective and possibly detrimental in non-CF bronchiectasis

Release 350 , 471485 (2022)

However, their integration into clinical practice is a challenging process because repeatability and the creation of easy analysis sets are more difficult (305)