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[PubMed: 659984] 518

Corre, J., van Zessen, R., Loureiro, M., Patriarchi, T., Tian, L., Pascoli, V., & Lscher, C

CREM, cAMP-responsive element modulator alpha

After centrifugation (7800 g

Aggregates of mutant polyQ proteins can be taken up by mitochondria, resulting in diminished mitophagy and aggravated mitochondrial dysfunction, subsequently leading to the increased production of reactive oxygen species (ROS) 7 and oxidative stress