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Description

Microglial activation occurs late during preclinical alzheimers disease

Estrela JM, Saez GT, Such L, Vina J

PSAT1 elevates GPX4 stability by promoting -ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation, disrupting its binding to HSC70 and inhibiting autophagy-mediated degradation