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When suggesting a mechanism for thiamines benefit to Parkinsons patients, the researchers pointed to research showing decreases of a brain enzyme related to thiamine 8 as well as research showing lower thiamine levels in the spinal fluid of Parkinsons patients 9

Given the low therapeutic doses (0.10.5 mg/kg), rapid onset of action, sustained efficacy, and the feasibility of repeated administration without triggering hepatotoxicity, inflammation, or an immune response, hMUT mRNA-based therapy represents a versatile and promising option for MMA treatment [296]

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