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[PMC free article: PMC2935934] [PubMed: 20802499] 162

Abstract One of the main complications of diabetes is diabetic foot ulcers (DFUs), which have a substantial global impact on morbidity, medical expenses, and lower limb amputations

-Lapachone-induced NQO1-dependent cell death has been reported in several cancers, including lung [137], breast [138], and liver cancers [139]

Causes of Oxidative Stress Several factors contribute to oxidative stress, including: Environmental Toxins: Pollution, cigarette smoke, and pesticides