In zero-order kinetics, a constant amount of drug is eliminated per unit time
Topical vs systemic administration in research In dermatological research GHK-Cu is used topically (creams, gels, masks) at concentrations of 0.1 to 2 %

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Systemically delivered drugs must cross the BBB, favoring small (under 500 Da) and lipophilic molecules for optimal absorption (Yadav et al., 2015)
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