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To determine whether the failure of Ect2 to localize to cell borders under DP KD conditions was due to concurrent perturbations to AJs, we sought to assess the status of the cardiac AJ components, -catenin and N-cadherin, via immunofluorescence analysis in a DP-deficient background

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In addition, given that the factors that induce ferroptosis in these different autoimmune diseases remain largely unclear, cytokines such as TNF- and IFN- regulate ferroptosis in different manners and contribute in various ways to disease pathogenesis ( Practically, there are many different approaches to block ferroptosis: pharmacologically using thiazolidinediones to inhibit ACSL4 activity, restoring the level of the key ferroptosis regulator Gpx4, administering ferroptosis-specific inhibitors such as ferrostatins and liproxstatins, preventing lipid peroxidation with supplementation of fatty acids, iron chelators and antioxidants, or modulating metabolic pathways ( - to induce ferroptosis in tumors ( Knowing that apoptosis and other cell death subtypes are also observed in IECs from patients with UC and CD ( Funding This work was supported by grants from the Ministry of Science and Technology (MOST 110-2314-B-182A-127-MY3) and Chang Gung Memorial Hospital (CMRPG1M0021), Taiwan, R.O.C

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