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Naturally present in the human body, GHK-Cu levels decrease with age, hence the interest in its potential to counteract some effects of aging

Thus, while the role of FOXO in mediating transcriptional regulation by IIS shows some evolutionary conservation, the IIS-regulated target genes of FOXO may be conserved only at the level of the gene families and the biological processes that they control - not at the level of orthology

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Therefore, we chemically synthesized the relevant macrocycles with C-terminal (-alanine) 2 -FLAG tags (A 2 -FLAG), with the resulting peptides referred to as aML5-FLAG, aMD4-FLAG and aMD5-FLAG (Supplementary Table 2 and Supplementary Fig

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