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W.GonzalezD.et al (2020)

Gut-Brain Axis Dysfunction MSG can damage the vagal nerve , alter gut microbiota , and increase intestinal permeability , contributing to: Histamine intolerance IBS or IBD flare-ups Symptoms of MSG Sensitivity Headaches or migraines Numbness or tingling Facial pressure or chest tightness Heart palpitations Sweating or flushing Brain fog or cognitive slowness Mood swings or irritability Joint stiffness or muscle pain Symptoms may appear within 30 minutes or up to 24 hours after exposureoften leading to missed connections

Moreover, a different group, also utilizing functional imaging in resting-state euthymic, older bipolar adults, discovered increased amygdala, parahippocampal, and anterior temporal cortical activity, combined with decreased dorsolateral PFC activity

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