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We observed that a ferroptosis-like mechanism, induced by xCT inhibition with Erastin, at a non-lethal level, promoted features of ECs activation, such as proliferation, migration and vessel-like structures formation, concomitantly with the depletion of reduced glutathione (GSH) and increased levels of oxidative stress and lipid peroxides

Safety, Risks, and What the Research Actually Says BPC-157 has one of the cleanest safety profiles in the peptide research literature

10.1016/j.abb.2019.108241 12

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Reduces absorption rate and increases localized irritation