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were the three most common ( Streptococcacae, Veilonellacae , and Prevotellacae have been described by other authors as the dominant bacterial phyla in the healthy esophagus by 16Sr RNA sequencing technology ( 2.2 Esophageal microbiome in reflux The microbiome changed with the spatial structure of the esophagus

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Such biomarkers have been identified for genetic variations, oxidative stress, inflammation, and neurotrophic factors, among others (Rowland et al., 2018), and some have shown promise for monitoring course of illness, tracking treatment outcomes, and informing clinical decision-making

doi: 10.1038/s41551-021-00766-1 57 Reticker-FlynnNEZhangWBelkJABastoPAEscalanteNKPilarowskiGOWet al