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Biochim Biophys Acta BBA-Gen Subj 1790(11):14291440

We encounter free radicals when were stressed, drinking too much, or exposed to environmental pollution, toxins, or UV rays

For the IFN-I bioassay, 5 10 4 3T3 cells containing an interferon-sensitive response element (ISRE) fused to luciferase 51 were plated per well into 96-well white-bottom plates (Greneir 655083) in DMEM containing 10% FBS, 100 U/ml penicillin and 100 g/ml streptomycin

Here we apply cryogenic electron microscopy imaging (cryo-EM) to show how interfaces on both of AIMs C-terminal SRCR domains interact with the Fc constant region and J chain components of the IgM core

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