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In adipose tissue, 5-LOX interruption leads to a remarkable insulin-sensitizing effect by increasing PPAR expression, IRS1 activity, and adiponectin level that is accompanied by reduced inflammatory response

For example, some participants have type 2 diabetes and others do not

Subsequently, repair or degeneration occur, which depend on multiple factors such as the type and extent of damage, the immune system, the genetic susceptibility to disc degeneration, which is linked with age, the biomechanical (functional) condition that is created by the injury, and finally the type of treatment: conservative (disc loading) or operative (disc unloading)

& Koo, C

Dong et al., 2000)