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Conclusion: AB4 directly targets RAGE to inhibit the AGE/RAGE-Nrf2 axis, thereby suppressing both ferroptosis and inflammation in SALI

Because iron is indispensable for wrapping myelin and powering metabolic enzymes, oligodendrocytes outrank every other CNS cell population in intracellular iron content (Friedrich et al., 2021

For example, Lo and colleagues (2016) reported that obesity failed to promote tumorigenesis in localized patient-derived prostate cancer xenografts in severe combined immunodeficiency (SCID) mice (13)

Direct evidence of DJ-1s role in neuronal survival against ferroptosis comes from studies showing that dopaminergic neurons differentiated from induced pluripotent stem cells of PARK7 mutant carriers exhibit increased sensitivity to ferroptosis (93)