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Grants APQ-02904-24

As a core regulatory factor, STAT3 can be activated by various molecules, including specific cytokines, peptide ligands, growth factors, and products of oncogenes, thereby integrating multiple signaling pathways [338, 339]

Although there are still challenges in standard production, targeted delivery efficiency, and the elucidation of the mechanism of action, with the deepening of research and the breakthrough of technical bottlenecks, exo therapy is expected to drive the treatment of SCI from the traditional palliative support model to a new era centered on precise regulation, promotion of nerve regeneration, and circuit remodeling

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Moreover, our data suggest that high ABCC1 expression predicts poor response to Venetoclax therapy