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Leise TL, Harrington ME, Molyneux PC, Song I, Queenan H, Zimmerman E, Biello SM (2013) Voluntary exercise can strengthen the circadian system in aged mice

However, sustained ERS may also promote immune escape through exosomal miR-27a-mediated PD-L1 upregulation [110], underscoring the importance of temporally controlled therapeutic strategies

Nutraceuticals and natural products have been shown to possess some sort of beneficial effect in the improvement of fatigue and associated symptoms, with a favorable safety profile (Luo et al