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Hemoglobin-based oxygen carriers: clinical application of HBOC-201 as an alternative to red blood cells for machine perfusion in liver transplantation

In activated macrophage cultures, GHK-Cu administration reduces the production of pro-inflammatory cytokines including interleukin-1, tumor necrosis factor-, and interleukin-6 by 40-65% while simultaneously increasing the production of anti-inflammatory mediators such as interleukin-10 and transforming growth factor-