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Continuous oxidative damage to mtDNA has been linked to aging, inflammation, carcinogenesis, and the development of malignancy [47]

In the SURPASS clinical trial program in type 2 diabetes mellitus (T2D), tirzepatide was associated with unprecedented reductions in HbA1c, clinically significant weight loss and other metabolic benefits, combined with low rates of hypoglycaemia across a wide range of patient characteristics

Chemokines binding to specific receptors on the target cell membrane help to recruit immune cells into the tumor microenvironment, thereby managing immune surveillance, angiogenesis, invasion and metastasis (96)