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Diabetes Care 2022;45:276-84

In some embodiments, preparation of certain cations of the invention may occur via oxidation of quinoline (using e.g., mCPBA) followed by nitration and chlorination, respectively and further followed by amination and alkylation, respectively, as exemplified with the preparation of cation 2k (Scheme 4)

& Malenka, R

This may further ascertain the attenuated isoprenaline course (Figure 20)

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