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doi: 10.1378/chest.101.4.1160

Mei J, Xu D, Wang L, Kong L, Liu Q, Li Q, et al

E., Shimada, K., Skouta, R., Viswanathan, V

In contrast to ASXL1 1-591 , ASXL1 1-645 simultaneously and independently interacts with BRD4 and the H3K4-specific methyltransferases MLL3/4, whereas the shorter variant is lacking the MLL3/4-binding site and interacts only with BRD4

Similarly, MRTX849 treatment decreased intratumoural immunosuppressive myeloid-derived suppressor cells and M2-polarised macrophages and increased immune-promoting M1-polarised macrophages, dendritic cells, and CD4 + and NKT cells in KRAS (G12C) tumours by altering the expression of tumour RNA and protein implicated in the presentation of tumour antigens or mediating an immunosuppressive TME 204