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It is strongly associated with the development and progression of hepatic steatosis, increased oxidative stress, mitochondrial dysfunction, activation of pro-inflammatory and pro-fibrotic pathways, and systemic metabolic dysregulation

While all cells can synthesize glutathione for use within the cell, the liver also produces glutathione in larger amounts and exports it into the plasma and bile

Hirai MY, Klein M, Fujikawa Y, Yano M, Goodenowe DB, Yamazaki Y, Kanaya S, Nakamura Y, Kitayama M, Suzuki H, Sakurai N, Shibata D, Tokuhisa J, Reichelt M, Gershenzon J, Papenbrock J, Saito K (2005) Elucidation of gene-to-gene and metabolite-to-gene networks in Arabidopsis by integration of metabolomics and transcriptomics

Many questions remain to be explored in depth

Antagonism of HOX/PBX dimer formation blocks the in vivo proliferation of melanoma