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This adaptive response may be caused by mutations that deactivate or activate tumor suppressor genes or oncogenes under hypoxic conditions

Acta Anat (Basel) 1958;34:187-200

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567,568 CD14 + monocytes isolated from the blood of RA patients and individuals at risk have shown higher levels of glycolytic enzymes, including HIF-1, HK2, and PFKFB3, than those from healthy individuals