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Description

conducted the present pilot study [2] to examine the ratio of acylcarnitines to free carnitines (AC/FC), a biomarker of cardiomyocyte carnitine insufficiency and impaired -oxidation [3], either in symptomatic HF with reduced left ventricular ejection fraction (LVEF) HFrEF or HF with preserved LVEF (HFpEF), and demonstrated that AC/FC levels in admission were significantly higher than in asymptomatic staged HF, decreasing to comparable levels at discharge

L-Carnitine is a biologically active amino acid derivative that has a key role in the regulation of fatty acid metabolism and adenosine triphosphate formation in multiple organs

vol.42 no.4 Toledo jul./ago

Impaired presynaptic vesicle pool storage and ineffective or malformed presynaptic terminal formation have been demonstrated in multiple animal models of hereditary ALS [284, 285]