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Patients with complete response to first locoregional therapy (LRT) were excluded (ICI n=18, UNOS-DS n=103, AC n=36)

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Glial cells in (patho)physiology

JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment

Both the innate and adaptive responses have a central role in the chronic tissue injury and epithelial damage that represent SLE ( Probiotics have been shown to have immunomodulatory effects that are particularly intriguing in relation to controlling the immunological responses in individuals with SLE ( Figure 2 ) ( Figure 2 3.4.1 Probiotics impact on innate immune response Probiotics, especially Lactobacillus, have been shown to be able to attain the remarkable capability of enhancing neutrophil functionality by secreting exopolysaccharides (EPS) that activate the TLR2/MyD88 signaling pathway, thereby facilitating chemotaxis and phagocytosis